One of the most important concerns which have coerced organizations to illustrate tendency toward entrepreneurial activities is survival and growth. This is, thus, to assert that time is ripe for investigating the relationships between entrepreneurial behavior and performance. This study is aimed at investigating the relationship between entrepreneurial orientations and organizational performance of the Islamic Research Institute for Culture and Thought in 2013. To do so, descriptive and correlative research methodologies were used to examine the relationships among these variables. Statistical population of this study contains a number of university staffs at different managerial levels, members of Faculty Board, and experts, who are estimated to constitute 110 persons from the total number of 320. Pearson correlation and multivariable regression methods were used to analyze data. Moreover, Structural Equation Model (SEM) was employed to affirm the model. Results show that there is a positive and direct relationship between entrepreneurial orientation and organizational performance. In addition, there is indirect relationship among innovation, leadership, risk-taking, and aggressive competition as aspects of entrepreneurial orientation, on the one hand, and organizational performance, on the other. However, there was no relationship between independence and organizational performance. Therefore, development of attitude and attention to entrepreneurial orientation in an organization can be effective in elevating organizational performance.